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Compartment

Bible DictionaryAids Glossary
a separate structural portion (e.g., of the body or of a cell). The term is also used in pharmacology to denote an area of the body where a drug is metabolized, but which may not have a discrete physical boundary.
Bible DictionaryToxicology Dictionary
As used in toxicokinetics, compartment is a hypothetical volume of a body system wherein a chemical acts homogeneously in transport and transformation. The body is composed of organs, tissues, cells, cell organelles, and fluids, any one or several of which may be referred to as a compartment.
Bible DictionaryPharmacology Glossary
The space or spaces in the body which a drug appears to occupy after it has been absorbed. Pharmacokinetic compartments are mathematical constructs and need not correspond to the fluid volumes of the body which are defined physiologically and anatomically, i.e., the intravascular, extracellular and intracellular volumes. Some drugs make the body "behave" as if it consisted of only a single pharmacokinetic compartment. Tissue and plasma concentrations of the drug rapidly and simultaneously reach equilibrium in all the tissues to which the drug is distributed. A plot of plasma concentration against time after intravenous administration can be rectified into only a single straight line of negative slope, which can intersect the ordinate at only one point; only one volume of distribution can be calculated. Hence, the existence of only one compartment or volume of distribution can be inferred. Some drugs make the body appear to consist of two or more pharmacokinetic compartments, since tissue/plasma equilibrium is achieved at different times in different tissues or groups of tissues. A plot of plasma concentration against time after intravenous administration can, at best, be resolved into a series of connected straight-line segments with progressively decreasing slopes. Each of these segments may be extrapolated to intersect the ordinate, and one may infer the existence of as many pharmacokinetic compartments, of volumes of distribution, for the the drug as there are intersections or segments. Compartments in which equilibrium is achieved relatively late are referred to as "deep" compartments; compartments in which equilibrium is achieved early - and from which drug is redistributed to other sites - are referred to as "shallow" or "superficial" compartments.Cf. a , b , Volume of Distribution , Vd (Vd)
See also: D & C , QC , N.D. , A band , QD

 

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A
A & E
A Course in Mir...
A band
A&P
A-hydroCort
A.C.&C
A.E.
A.E.R.
A.P.L.
A.T.C.
A B Otic
A G
A O
A T S
A1AT
A1C
A2
A33
AA
AAA
AAAS
AABB
AACC
AACP
AACTG
AACTN
AAD
AADRC
AAFP
AAH
AAI
AAIAC
AAIDCRC
AAN
AAO
AAOS
AAOx3
AAP
AAPB
AAPMR
AAROM
AASLD
AAT
AAV
ABACAVIR
ABC
ABCA
ABCB
ABCD rating
ABCL
ABD
ABDOM
ABG
ABI-007
ABM
ABNT
ABO
ABO Antigens
ABO Blood Group
ABO Incompatibi...ABO blood groups
ABO system
ABP
ABT-510
ABT-751
ABVD
ABW
ABX-EGF
AC
AC and C
ACA
ACAI
ACAS
ACC
ACCESS (Access ...ACCOMMODATION
ACDP
ACDS
ACE
ACE Inhibitor
ACE inhibitor
ACE inhibitors
ACES
ACG
ACGIH
ACGM
ACIO
ACL
ACLS
ACMD
ACOG
ACOP
ACP
ACQUIRED IMMUNO...ACRE
ACT
ACTG
ACTG 076

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